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ORIGINAL ARTICLE
Year : 2019  |  Volume : 3  |  Issue : 1  |  Page : 39-41

Effect of ATP-Binding cassette, Sub-Family B polymorphism on plasma nevirapine and efavirenz levels in human immunodeficiency virus with tuberculosis-infected cases: A molecular structure analysis


1 TWS Medical Center, Bangkok, Thailand
2 Department of Biological Science, Josepeh Ayobabalola University, Ikeji-Arakeji, Osun State, Nigeria

Correspondence Address:
Dr. Pathum Sookaromdee
TWS Medical Center, Bangkok
Thailand
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/bbrj.bbrj_23_19

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Background: Tuberculosis (TB) is an important infection that is usually seen in the patient with underlying human immunodeficiency virus (HIV) infection. An important concern on the cases with HIV/TB is the management of HIV by antiretroviral drug treatment (antiretroviral therapy). The effect of underlying genetic factor is interesting. The effect of adenosine triphosphate-binding cassette, sub-family B (ABCB-1) polymorphism on plasma nevirapine and efavirenz levels is inconclusive. Methods: The authors perform standard molecular structure analysis to assess the effect of C and T alleles of ABCB-1 C3435T polymorphism. The phenotype expressions, reflected by nevirapine and efavirenz levels, are comparatively studied. Results: With focus on 3435 position, the ratio of derived molecular weight after quantum assessment, comparing CC to CT and TT genotypes, is equal to 1:1.068:1.135. Conclusion: The authors can identify the effect of ABCB-1 on the plasma nevirapine and efavirenz levels in HIV/TB patients.


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