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REVIEW ARTICLE
Year : 2019  |  Volume : 3  |  Issue : 3  |  Page : 140-146

Evaluation of the therapeutic, diagnostic, and prognostic means currently applied to counter the surge of tuberculosis


Parabolic Biologicals, Rue de l' Ecluse, 2, 1320 Beauvechain, Belgium

Correspondence Address:
Prof. Roland Maes
Parabolic Biologicals, Rue de l' Ecluse, 2, 1320 Beauvechain
Belgium
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/bbrj.bbrj_71_19

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The bacilloscopy and culture, the skin test, the BCG vaccine and the discovery of five powerful anti-TB chemicals were assumed sufficient to win the war on TB after World War II but the enigmas and paradoxes uncovered during treatment were given no heed and the humoral immune capacities of the patient were totally ignored. TB resurged at the turn of the century, with a vengeance. The patient suffering from a TB infection mounts a humoral immune response that is as important as a cellular immune reactivity and is useful as a prognostic of treatment outcome and as a diagnostic of latent infections. The anti-TB chemicals are expensive, highly toxic and some destroy the immunocytes of the patient. Their use may provoke a drastic plunge of antibodies' production, which leaves the patient deprived of immunological resources and exposes the successfully treated patient to relapse. The monitoring of the IgG class of anti-TB antibodies synthetized by a subject suffering from a latent infection prone to convert allows the detection of these cases. At the onset of diagnosed cases, the level of these antibodies is sometimes very low, indicating an immunodepression generated by the pathogen. The monitoring of the rise of their production during treatment permits a control of the efficacy of the treatment. A food supplement consisting of RNA oligonucleotides is available, whose property is to stimulate the multiplication of leucocytes and platelets.


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