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 Table of Contents  
EDITORIAL
Year : 2020  |  Volume : 4  |  Issue : 1  |  Page : 1-2

The effectiveness of cold atmospheric plasma by inhaling anesthetic mask or through bronchoscopy against COVID-19


1 Mycobacteriology Research Center, National Research Institute of Tuberculosis and Lung Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Mycobacteriology Research Center, National Research Institute of Tuberculosis and Lung Disease; Department of Biotechnology, School of Advanced Technology in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 Laser and Plasma Research Institute, University of Shahid Beheshti, Tehran, Iran

Date of Submission27-Feb-2020
Date of Acceptance04-Mar-2020
Date of Web Publication17-Mar-2020

Correspondence Address:
Dr. Jalaledin Ghanavi
Mycobacteriology Research Center, National Research Institute of Tuberculosis and Lung Disease, Shahid Beheshti University of Medical Sciences, Tehran
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/bbrj.bbrj_27_20

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How to cite this article:
Ghanavi J, Farnia P, Ghomi H. The effectiveness of cold atmospheric plasma by inhaling anesthetic mask or through bronchoscopy against COVID-19. Biomed Biotechnol Res J 2020;4:1-2

How to cite this URL:
Ghanavi J, Farnia P, Ghomi H. The effectiveness of cold atmospheric plasma by inhaling anesthetic mask or through bronchoscopy against COVID-19. Biomed Biotechnol Res J [serial online] 2020 [cited 2020 May 25];4:1-2. Available from: http://www.bmbtrj.org/text.asp?2020/4/1/1/280879



Coronaviruses (CoVs) are a large family of viruses that cause illness ranging from the common cold to more severe diseases such as Middle East respiratory syndrome-CoV and severe acute respiratory syndrome (SARS-CoV).[1] Following the first reports of cases of acute respiratory syndrome in the Chinese Wuhan municipality at the end of December 2019, Chinese authorities have identified a novel coronavirus as the main causative agent. Real-time PCR (RT-PCR) assays on these samples were positive for pan-Betacoronavirus. Using Illumina and nanopore sequencing, the whole genome sequences of the virus were acquired. Bioinformatic analyses indicated that the virus had features typical of the coronavirus family and belonged to the Betacoronavirus 2B lineage named as COVID-19. The outbreak has rapidly evolved affecting other parts of China and outside the country. Cases have been detected in several countries not only in Asia, but also in Australia, Europe, Africa, and North America.[1] Further global spread is likely. It is mainly spread through respiratory droplets from one person to another and is considered a prominent threat to public health, as there has been no confirmed treatment to control its activity. The transmissibility of CoV is 2.9 (the average number of secondary cases generated per infectious case) compared to that of SARS which was 1.7 based on effective reproductive number.

The spike protein (S)[2] and nucleocapsid protein (N-protein) are encoded by all CoVs, including the coronavirus (COVID-19). The spike protein (S) of COVID-19 is a heavily glycosylated Class I of fusion proteins, which binds to the receptor on the host cell and mediates viral entrance and determines cell tropism and pathogenesis. The spike protein contains cysteine-rich domain which induces CoV–host cell membrane fusion. Therefore, modification of spike protein can be influential on virus pathogenicity. It is already known that cold atmospheric plasma (CAP) generates reactive oxygen species, such as singlet oxygen, reactive nitrogen species, electrons, ions, and photons, that is extensively used for bacterial and viral inactivation.[3] The potential applications of CAP have created a new field of study known as plasma medicine.[4]

Here, we proposed that CAP oxidation of cysteine is the best alternative for the alteration of CoV pathogenicity, if it is given by anesthetic mask or through bronchoscopy intubation to the infected patients. The practice of interventional Pulmonology that placed the CAP through a bronchoscope or or by inhaling through anesthetic mask are not yet fully understood. However, as it seems that production of singlet oxygen might react with cysteine-rich domain of spike S protein of COVID-19, this might lead to aggregation of COVID-19. Additionally, it prevents the fusion of virus to host cells. At this time, using this rapid methodology both to reduce the attachment of COVID-19 in the host cell and Induction of apoptosis in infected cell with covid-19 that cased to stimulation” immune response against them [Figure1].
Figure 1: Rapid method to reduce the attachment of COVID-19 by cold atmospheric plasma

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  References Top

1.
World Health Organization. COVID-19. Available from: https://www.who.int/health-topics/coronavirus. [Last accessed on 2020 Feb 12].  Back to cited text no. 1
    
2.
Guo L, Xu R, Gou L, Liu Z, Zhao Y, Liu D, et al. Mechanism of Virus Inactivation by Cold Atmospheric-Pressure Plasma and Plasma-Activated Water. Appl Environ Microbiol 2018;84:e00726–e00718. 10.1128/AEM.00726-18.  Back to cited text no. 2
    
3.
Lieberman MA, Lichtenberg AJ. Principles of Plasma Discharges and Materials Processing. 2nd Edition. Hoboken, New Jersey: A John Wiley & Sons, Inc Publication; 2005. p. 1-800.  Back to cited text no. 3
    
4.
Chen Z, Li G, Wu Z, Xia Y. The crack propagating behavior of composite coatings prepared by PEO on aluminized steel during in situ tensile processing. Mater Sci Eng A 2011;528:1409-14.  Back to cited text no. 4
    


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