• Users Online: 620
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2020  |  Volume : 4  |  Issue : 1  |  Page : 69-75

Protective effect of lycopene against tamoxifen-induced hepatotoxicity in albino rats


Department of Pharmacology and Toxicology, Faculty of Pharmacy, Niger Delta University, Bayelsa State, Nigeria

Correspondence Address:
Dr. Elias Adikwu
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Niger Delta University, Bayelsa State
Nigeria
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/bbrj.bbrj_3_20

Rights and Permissions

Background: Tamoxifen citrate (TAM) is a drug of choice for the treatment of hormone-dependent breast cancer, but its use has been associated with frequent hepatotoxicity. Aim: This study evaluated the protective effect of lycopene (LYP) against hepatotoxicity induced by TAM in albino rats. Methods: Adult female albino rats (200–250 g) were divided into eight groups of n = 5. Group 1 (control) received normal saline (0.2mL) intraperitoneally (i.p.), daily for 7 days. Groups 2–4 were treated daily with LYP (10 mg/kg, 20 mg/kg, and 40 mg/kg) (i.p.) for 7 days, respectively. Group 5 was treated daily with TAM (45 mg/kg) i.p. for 7 days. Groups 6–8 were supplemented daily with LYP (10 mg/kg, 20 mg/kg, and 40 mg/kg) before treatment with TAM (45 mg/kg) i.p. for 7 days, respectively. At the end of treatment, the rats were anesthetized and blood samples were collected and assessed for serum markers of liver function. Liver samples were harvested for histology and biochemical assessments. Results: Significant (P < 0.001) elevations in serum and liver aminotransferases, lactate dehydrogenase, gamma glutamyl transferase, alkaline phosphatase, total bilirubin, and conjugated bilirubin levels were observed in TAM-treated rats when compared to control. Furthermore, significant (P < 0.001) elevations in liver malondialdehyde levels with significant (P < 0.001) decreases in glutathione peroxidase, superoxide dismutase, glutathione, and catalase levels were observed in TAM-treated rats when compared to control. Vascular congestion with necrotic materials and lipoid necrosis were observed in TAM-treated rats. However, TAM-induced hepatotoxicity was significantly attenuated in a dose-dependent fashion in rats supplemented with LYP 10 mg/kg (P < 0.05), 20 mg/kg (P < 0.01), and 40 mg/kg (P < 0.001) when compared to TAM. Conclusion: LYP may have clinical application in hepatotoxicity caused by tamoxifen.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed31    
    Printed0    
    Emailed0    
    PDF Downloaded7    
    Comments [Add]    

Recommend this journal