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ORIGINAL ARTICLE
Year : 2020  |  Volume : 4  |  Issue : 3  |  Page : 225-231

Evaluation of pro-inflammatory cytokine level in cases of idiopathic recurrent spontaneous miscarriage in Saudi Arabia


Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al-Kharj, Riyadh, KSA

Correspondence Address:
Dr. Poonam Tyagi
Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al-Kharj, Riyadh
KSA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/bbrj.bbrj_71_20

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Background: A balanced stimulation and action of T-helper type 2 (Th2) and type 1 (Th1) immune response is required for a successful embryo implantation and positive outcomes of pregnancy while specific pro-inflammatory cytokine levels either belong to Th1 or Th2 profile which may deteriorate the pregnancy causing miscarriage. Methods: This research study comprised two groups: Group I – pregnant women with a history of recurrent spontaneous miscarriage (RSM, n = 50) and Group II – healthy pregnant controls (n = 50). Blood was collected, and serum was analyzed for interleukin (IL)-6, IL-8, IL-12, IL-18, TNF-α, and interferon (IFN)-γ using ELISA kit. Results: Th1 activity (IL-8, IL-12, IL-18, TNF-α, and IFN-γ) was higher in study Group I irrespective of whether continuing their pregnancy or aborting in comparison to Group II controls (P < 0.001). On the other hand, Th2 activity (IL-6) was decreased in Group I patients (P < 0.001) as compared with normal control Group II. Conclusions: Patients with a history of RSM have significantly increased Th1 activity and decrease in Th2 activity in comparison to normal pregnant women without any history of spontaneous miscarriage in their past.


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