• Users Online: 261
  • Print this page
  • Email this page


 
 Table of Contents  
SHORT COMMUNICATION
Year : 2020  |  Volume : 4  |  Issue : 3  |  Page : 266-267

Coronavirus disease 2019 pandemic: Envisaging capacity building in the field of research to accomplish effective control


1 Department of Community Medicine, Medical Education Unit, Institute Research Council, Shri Sathya Sai Medical College and Research Institute, Sri Balaji Vidyapeeth – Deemed to be University, Chengalpet District, Tamil Nadu, India
2 Department of Community Medicine, Shri Sathya Sai Medical College and Research Institute, Sri Balaji Vidyapeeth – Deemed to be University, Chengalpet District, Tamil Nadu, India

Date of Submission28-Jun-2020
Date of Acceptance02-Jul-2020
Date of Web Publication12-Sep-2020

Correspondence Address:
Dr. Saurabh RamBihariLal Shrivastava
Professor, Department of Community Medicine, Shri Sathya Sai Medical College and Research Institute, Sri Balaji Vidyapeeth (SBV) – Deemed to be University, Tiruporur - Guduvancherry Main Road, Ammapettai, Nellikuppam, Chengalpet District - 603108, Tamil Nadu
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/bbrj.bbrj_104_20

Rights and Permissions
  Abstract 


The coronavirus disease-2019 (COVID-19) pandemic has created a sense of fear and raised major concerns over the preparedness of the national public health authorities to respond to infectious disease outbreaks. Even though, a lot of dimensions pertaining to the disease prevention, control and treatment need to be strengthened to mount an effective response plan against the novel infection, it is extremely essential to invest and make rapid progress in the research and development field to enhance our understanding about the disease. In-fact, multiple number of such projects have been funded in China to gain significant insights about the genomics of the causative virus, antiviral drugs, utility of traditional Chinese therapy, clinical trials, potential vaccines, better diagnostic tools and various animal models. In conclusion, in the global battle against the novel COVID 19 outbreak, the domain of research and development for coming out with better diagnostic tools, potential therapeutic agents, and vaccines need to be strengthened immensely. It is worth realizing that any advancements made in this regard will shape the way the infection will be tackled in the coming days.

Keywords: COVID-19 outbreak, China, Research and Development, World Health Organization


How to cite this article:
Shrivastava SR, Shrivastava PS. Coronavirus disease 2019 pandemic: Envisaging capacity building in the field of research to accomplish effective control. Biomed Biotechnol Res J 2020;4:266-7

How to cite this URL:
Shrivastava SR, Shrivastava PS. Coronavirus disease 2019 pandemic: Envisaging capacity building in the field of research to accomplish effective control. Biomed Biotechnol Res J [serial online] 2020 [cited 2020 Sep 22];4:266-7. Available from: http://www.bmbtrj.org/text.asp?2020/4/3/266/294851




  Introduction Top


The coronavirus disease 2019 (COVID 19) pandemic has created a sense of fear and raised major concerns over the preparedness of the national public health authorities to respond to infectious disease outbreaks.[1],[2] Since the emergence of the first case in the Wuhan city of China, a total of 9,843,073 cases and 495,760 deaths have been attributed to the novel viral infection as on June 28, 2020.[1] After the initial outburst of the cluster of cases in China, the disease has been reported in 215 other nations and territories, and the infection has an overall case fatality rate of 5%. It is worth noting that owing to the sustained and aggressive efforts of the public health authorities in China, the number of reported cases has significantly declined while it has shown a considerable rise in the other parts of the world.[1]

Research and COVID-19

Even though a lot of dimensions pertaining to disease prevention, control, and treatment need to be strengthened to mount an effective response plan against the novel infection, and it is extremely essential to invest and make rapid progress in the research and development field to enhance our understanding about the disease.[3] As the causative organism has been a novel virus, the majority of the epidemiological and clinical attributes of the disease are still not conclusively known, and thus, we are still finding it extremely challenging to contain the infection.[2],[3] The success in China was predominantly due to the massive nation wide integrated response and support from the policymakers and various other stakeholders, but the same might not happen in other nations (due to the weaknesses in the health care delivery system and other preexisting public health priorities).[2],[4]

Strengthening research and development activities

Among all these uncertainties about the causative virus and the prevailing anxiety and confusion among the general population, the best approach will be to strengthen the domain of research and development.[4] In fact, multiple number of such projects have been funded in China to gain significant insights about the genomics of the causative virus, antiviral drugs, the utility of traditional Chinese therapy, clinical trials, potential vaccines, better diagnostic tools, and various animal models.[4] At the same time, different epidemiological studies are also underway to clearly understand the various modes of disease transmission, the complete spectrum of clinical illness, and the predisposing factors which might account for a fatal outcome. The findings obtained from these studies will play an instrumental role in saving the lives of thousands of people by ensuring better prevention, early detection, and appropriate treatment of the disease.[2 4]

Research findings

The initial research has demonstrated close to 96% similarity of COVID 19 virus with Sudden Acute Respiratory Syndrome like virus, and till date, eight nucleic acid based methods and two colloidal gold antibody detection methods have been approved in China alone.[4] Further, in the field of diagnosis, our long term goal is to identify prognostic markers. In addition, serological tests are also being evaluated and assessed for establishing a retrospective diagnosis. These approved tests are expected to facilitate early detection of the cases, which will directly expedite the process of isolation and onward transmission of the infection and thus play an important role in the effective containment of the infection.[3],[4]

In addition, multiple number of clinical trials have been initiated to test the potency of different drugs(viz. Favipiravir, Chloroquine, Remdisivir, etc.,) in curing the disease.[4] The next step will be coming out with intravenous immunoglobulins as an intermediate goal in the process of research and development.[4] However, the most important goal of research and development activity will be to develop a safe and effective vaccine, starting initially from the development of animal models to mRNA candidate vaccines to finally inactivated candidate and subunit vaccines.[3],[4] All these research and development activities will require loads of financial support and dedication from the health authorities.[2 4]


  Conclusion Top


In conclusion, in the global battle against the novel COVID 19 outbreak, the domain of research and development for coming out with better diagnostic tools, potential therapeutic agents, and vaccines need to be strengthened immensely. It is worth realizing that any advancements made in this regard will shape the way the infection will be tackled in the coming days.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
World Health Organization. Coronavirus Disease 2019 (COVID-19) Situation Report – 160; 2020. Available from: https://www.who.int/docs/default-source/coronaviruse/situationn-reports/20200628-covid-19-sitrep-160.pdf?sfvrsn=2fe1c658_2. [Last accessed on 2020 Jun 29].  Back to cited text no. 1
    
2.
Lee A. Wuhan novel coronavirus (COVID-19): Why global control is challenging? Public Health 2020;179:A1-2.  Back to cited text no. 2
    
3.
World Health Organization; 2019 Novel Coronavirus (2019-nCoV): Strategic Preparedness and Response Plan. Geneva: WHO Press; 2020. p. 1-28.  Back to cited text no. 3
    
4.
World Health Organization. Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19). Geneva: WHO Press; 2020. p. 31-5.  Back to cited text no. 4
    




 

Top
 
 
  Search
 
Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)

 
  In this article
Abstract
Introduction
Conclusion
References

 Article Access Statistics
    Viewed48    
    Printed0    
    Emailed0    
    PDF Downloaded14    
    Comments [Add]    

Recommend this journal


[TAG2]
[TAG3]
[TAG4]