|Year : 2018 | Volume
| Issue : 1 | Page : 1-8
Probiotics: The marvelous factor and health benefits
S Vijayaram1, S Kannan2
1 Department of Biotechnology, Theni College of Arts and Science, Theni; Department of Environmental Studies, Madurai Kamaraj University, Madurai, Tamil Nadu, India
2 Department of Environmental Studies, Madurai Kamaraj University, Madurai, Tamil Nadu, India
|Date of Web Publication||5-Mar-2018|
Dr. S Vijayaram
Department of Biotechnology, Theni College of Arts and Science, Veerapandi, Theni - 625 534; Department of Environmental Studies, Madurai Kamaraj University, Madurai - 625 021, Tamil Nadu
Source of Support: None, Conflict of Interest: None
The aim of this study is well stated to address in recent advances on probiotics in the past 50 years. Probiotics are the living cell organisms. It is a presence in human and animal gut. The probiotic organisms are natural antibiotics in the human-animal gut. This reviews the main role mechanisms of action in probiotics such as probiotics are antibiotics, probiotics in antibacterial activity, probiotic action in fish gut bacteria, dietary supplements of probiotics, gastrointestinal microbiota of fishes, microbial community of the gastrointestinal tract of fish, bioactive compounds from probiotic bacteria, probiotic uses in cancer therapeutic applications, and applications of probiotics. The most common probiotics are used in many ways such as boosting the immune system, inhibition of pathogenic organism, prevention of cancer, reduction of inflammatory bowel disease, reducing cholesterol level, and synthesis of Vitamin A. Nowadays, food products are mainly involved in chemical preservatives. These preservative agents are causing the disease to affect the human health. The probiotic food products are used to the development of human-animal health.
Keywords: Antibiotic resistance, antimicrobial activity, bioactive compounds, gut microbes, probiotic, therapeutic applications
|How to cite this article:|
Vijayaram S, Kannan S. Probiotics: The marvelous factor and health benefits. Biomed Biotechnol Res J 2018;2:1-8
| Introduction|| |
The probiotic means simply life for originating from the Greek words “pro” and “bios.” The most commonly quote meaning was made by Fuller (1989). The probiotics are live microbial feed supplement which beneficially affects the host animal by improving its intestinal balance. This correct definition is still commonly referred to, despite continual contention. Today, probiotics are quite every day in health-promoting “functional foods” for humans, as well as therapeutic, prophylactic growth supplements in animal production human health.,, Other commonly studied probiotics include the spore-forming Bacillus spp. Yeasts. Bacillus spp. have been shown to possess adhesion abilities, produce bio activated molecules provide immunostimulation.,, Bacillus spp. hold an added interest in probiotics as they can be kept in the spore form and therefore stored indefinitely on the shelf. It is often reported that a probiotic must be adherent and colonize within the gastrointestinal tract (GIT), it must replicate to high numbers, it must produce antimicrobial substances, and it must withstand the acidic environment of the GIT.,,,, Lactic acid bacteria (LAB) have been widely used and researched for human terrestrial animal purposes; LAB are also known to be present in the intestine of healthy fish.
The most commonly used probiotic is LAB, namely, lactobacilli sp. are usually characterized by Gram-positive, nonmotile, nonsporulating bacteria that produce lactic acid as their main byproduct due to fermentation [Figure 1]. The use of probiotics for growth promoter in aquatic animals is increasing with the demand for environment-friendly sustainable aquaculture.
|Figure 1: Effects of dairy and biological products. Lactic acid bacteria are present in milk processing and naturally enrich fermented dairy products with a wide range of bioactive metabolites|
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Probiotics are reported to enhance by stimulating phagocytic activity, complement-mediated bacterial killing immunoglobulin production.,, The use of antibiotics to cure bacterial infection prevent fish mortality in aquaculture is becoming limited as pathogens develop resistance to drugs.
In the past decade, several scientists carefully examined the role effects of probiotics in aquaculture as an alternative to antimicrobial drugs, demonstrating positive effects on fish survival, growth, stress resistance, immune system enhancement, finally general welfare [Figure 2]. The importance of probiotics in human-animal nutrition is widely recognized.,
|Figure 2: Beneficial effects of probiotics in aquaculture. Blue arrow indicates additive effects. Red lines indicate inhibitory effect|
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The role of probiotics in nutrition health of certain aquaculture species has also been investigated by Fuller, Balcázar et al., Rinkinen et al., and Lara-Flores and Olvera-Novoa.,,
Mechanisms of action of probiotics
Probiotic bacteria can inhibit pathogens by the production of antagonistic compounds/by competitive exclusion (competition for nutrients attachment sites). Probiotic bacteria directly take up or decompose the organic matter and improve the water quality of an aquatic ecosystem. Beneficial microbial cultures produce a variety of exoenzymes such as amylase, protease, and lipase, which help to degrade the unconsumed feed feces in the pond, in addition to the possible role of these enzymes in the nutrition of the animals by improving feed digestibility and feed utilization. Among all the microbial interventions to augment the production, use of probiotics is in the central dogma. The modes of action of probiotics include the inhibition of a pathogen through the production of bacteriocin-like compounds, competition for attachment sites, competition for nutrients (particularly iron in marine microbes), alteration of the enzymatic activity of pathogens, immunostimulatory functions, and nutritional benefits such as improving feed digestibility and utilization [Figure 3].,,
|Figure 3: Four different methods of protecting probiotics from the intestines against known diseases. Probiotics compete against pathogens for essential nutrients and are less likely to be used for pathogens (a). They attach to adhesion sites and reduce pathogen dependence by reducing the available ground surface for pathogenic colonization (b). Signaling of immune cells by probiotics leads to secretion of cytokines and targeting the pathogen for destruction (c). Ultimately, probiotics with direct bacterial release of bacteriocins (d)|
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Probiotics in antibiotics
Probiotics have also been reported to stimulate the immunological system, counteract allergies decrease cholesterol level. Microbial drugs are making their continuous influence as cancer chemotherapeutic agents. The discovery of actinomycin has led to venture into a microbial world in the quest for anticancer compounds. Among the approved products deserving special attention are Actinomycin D, anthracycline, bleomycin, (mithramycin, streptozotocin, and pentostatin), calicheamicin, and taxol epothilones. Actinomycin, an antibiotic isolated from Streptomyces antibiotics, has served well against Wilms tumor in children.,
Probiotics in antibacterial activity
The beneficial effects of probiotics have been attributed to their ability to promote the immunological and nonimmunological defense barrier in the gut; normalization of increased intestinal permeability altered gut microflora. Twelve different intestinal bacterial colonies were isolated from black tiger shrimp (Penaeus monodon).
Among them, a bacterium, Bacillus subtilis strain was studied and characterized due to antagonistic properties against three target pathogenic bacterial strains of Vibrio alginolyticus, Vibrio harveyi, and Vibrio vulnificus.,
Several bacteria have been reported as pathogenic to fish. Among them, six Gram-negative rods (Aeromonas, Proteus, Citrobacter, Pseudomonas, and Flavobacterium Chromobacterium) and three Gram-positive cocci (Micrococcus and Streptococcus Staphylococcus) have been reported for their pathogenicity.
Probiotic action in fish gut bacteria
The use of probiotic for aquatic animals is increasing with the for environment-friendly sustainable aquaculture. The gut microbiota of aquatic animals is probably constituted by indigenous microbiota jointly with artificially high levels of microorganisms so maintained by their constant ingestion from the surrounding water. Probiotic strain increased the survival of larvae of the crab and Portunus trituberculatus also reduced the amount of Vibrio sp. in the water used to rear the larvae.,,, Subsequently, it has been reported that bacterial strains associated with intestinal skin mucus of adult marine turbot (Scophthalmus maximus) dab (Lima lima), suppressed the growth of the fish pathogen V. anguillarum.,
The overall completed study revealed that the isolated Bacillus spp. fulfill the required criteria for probiotics such as acid tolerance, bile salt tolerance, autoaggregation, antibiotic resistance, and antimicrobial activities to harsh conditions; it can be produced bacteriocin extracellular which inhibits pathogenic organisms. These isolates were used for potential probiotics [Table 1].
Dietary Supplements of Probiotics
Dietary supplements such as probiotics originally defined as live microbial feed supplements that beneficially affect the intestinal microbial balance of the host organism , and have received heightened attention in aquaculture over the past several years.,, The symbiotic and pathogenic organisms are affected by prebiotics are played important roles in several processes as well as growth, digestion, and immunity disease resistance of the host organism as demonstrated in poultry,, other terrestrial livestock companion animals,, as well as in humans [Table 2]., At this time, the application of prebiotics in aquaculture has been rather limited but holds considerable potential. However, to effectively apply prebiotics or probiotics in aquaculture, the microbial community of finfishes has to be better characterized understood.
| Gastrointestinal Microbiota of Fishes|| |
The GIT of invertebrates' vertebrates provides habitat for a diverse ecosystem of microorganisms. These microorganisms play an important role in the health nutrition of the host. The vertebrate GIT is predominantly an anaerobic environment; the GIT microbial community of fishes, especially the anaerobic microbial community, is poorly studied and understood. The majority of studies characterizing the fishes' intestinal microbial community have been aerobic studies,, which consequently determined the dominant facultative anaerobic bacteria, but did not cultivate the strictly anaerobic bacteria. Using aerobic methods to culture bacteria have led some investigators to conclude that anaerobic bacteria play a minor role in the GIT microbial community of fishes. For example, Spanggaard et al. concluded that the anaerobic microbial community was a minor component of the GIT microbial community of rainbow trout Oncorhynchus mykiss because the plate count estimates direct count estimates produced similar results. However, it is impossible to determine microbial species using microscopic direct count methods, even if the estimates were similar, the species counted cultured could be different. The isolate characterization of anaerobes from the GI tract of fishes; the first was reported by Trust et al. (1979). They isolated bacteria from the GIT of grass carp Ctenopharyngodon idelly, goldfish Carassius auratus, and rainbow trout. The bacteria identified were largely unknown Anaerobic bacteria were next isolated from the intestinal tract of various freshwater fish species.,
| Microbial and Ecology of the Gastrointestinal Tract of Fish|| |
The dominant bacterial species isolated was not specifically described but was cellulolytic thus may help the host to digest plant materials. Anaerobic studies of the GIT of fishes are essential to fully characterize the microbial community of the host and evaluate the effects of dietary supplements designed to stimulate specific beneficial bacteria. The limited use of strict anaerobic techniques has led to some faulty conclusions. However, their sampling procedure for intestinal microbiota exposed the intestinal contents to oxygen before transfer to an anaerobic bag; thus any obligate anaerobes might have been killed. In addition, the samples were placed on dry ice (−20°C) for up to 96 h, which is lethal to some microorganisms., Weinstein et al. (1982) observed that the intestinal tissue appeared to be the source of the cellulose the intestinal contents had very little if any cellulase activity. However, even after washing the GI tissues thoroughly with water, cellulolytic bacteria may still adhere to the walls of the intestinal lumen and exhibit cellulase activity.
| Bioactive Compounds from Probiotic Bacteria|| |
The fish GIT is populated with the complex microbial community. It plays a vital role in promoting the health of the host through the production of secondary metabolites. Probiotic bacteria may produce types of secondary metabolites. The bacterial bioactive compounds are used to inhibit the growth of the human fish pathogens.,
The microbial extraction of different bioactive molecules as a valuable source has served in drug discovery efforts in the isolation of several important drugs. The chemical composition of bioactive compounds of microbial origin is often highly complex [Figure 4].
|Figure 4: Summary of gastrointestinal (red), nongastrointestinal (blue) and neoplastic (green) disorders that are currently known to respond to probiotics|
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| Probiotic Uses in Cancer Therapeutic Applications|| |
Probiotics, an example of a functional food, have been the focus of intense research activity in recent years and have been defined as “living microorganisms which upon ingestion in certain numbers exert health benefits beyond inherent general nutrition.” The list of beneficial effects attributed to probiotic bacteria is extensive  that includes alleviation of lactose intolerance symptoms; serum cholesterol reduction; anticancer effects alleviating constipation, relieving vaginitis to name but a few (joseph rafter) studies have shown that probiotic bacteria prevent putative preneoplastic lesions or tumors induced by carcinogens such as 1,2-dimethylhydrazine or azoxymethane.,, Many strains such as Lactobacillus rhamnosus GG,,Lactobacillus acidophilus,,Lactobacillus casei, Bifidobacterium longum,,Bifidobacterium infantis, Bifidobacterium adolescentis, and Bifidobacterium breve showed significant suppression of colon tumor incidence [Figure 5]. In addition, there is direct evidence for antitumor activities of LAB obtained in studies using preimplanted tumor cells in animal models.
|Figure 5: Mechanism of different probiotic action in colon cancers,,,,|
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Antitumor activity found in peptidoglycans  isolated from B. infantis strain ATCC 15697 reported antitumor polysaccharide fractions originating from Lactobacillus cultures. Nowadays, food is no longer considered by consumers only in terms of taste, immediate nutritional needs but also in terms of their ability to provide specific health benefits beyond their basic nutritional value. The largest segment of the functional food market is dominated by healthy food products targeted toward improving the balance activity of the intestinal microflora in recent years. The probiotics are suppressed the harmful bacteria by controlling pH of the large intestine through the production of lactic, acetic acids.
Microbial-based therapy of cancer is one of the emerging cancer treatment modalities. Important advancements have been made to study develop live bacteria or bacterial products such as proteins, enzymes, immunotoxins secondary metabolites of bacteria fungi which specifically target cancer cells cause tumor regression through growth inhibition, cell cycle arrests or apoptosis induction.
| Probiotics as Agents|| |
Probiotic bacteria have antiviral effects. The mechanism of probiotic bacteria do this is not known, laboratory tests show that the inactivation of viruses can occur by chemical biological substances, such as extracts from marine algae extracellular agents of bacteria. It has been reported that different type of bacterial strains such as Pseudomonas sp, Vibrios sp, Aeromonas sp, groups of coryneforms isolated from salmonid hatcheries, these bacterial are showed antiviral activity against infectious hematopoietic necrosis virus (IHNV) with >50% plaque reduction. Girones et al. (1989) reported that a marine bacterium, tentatively classified in the genus Moraxella More Details, showed antiviral capacity, with high specificity for poliovirus. Direkbusarakom et al. isolated two strains of Vibrio spp. from a black tiger shrimp hatchery displayed antiviral activities against IHNV Oncorhynchus masou virus (OMV), with percentages of plaque reduction between 62% and 99%, respectively.
| Applications of Probiotics|| |
The use of probiotics as beneficial bacteria, which control pathogens through a variety of mechanisms, is increasingly viewed as an alternative to use antibiotics. The use of probiotics in the human animal for the nutritional purpose was well documented ,,, recently; they have begun to apply in aquaculture.,,, Some benefits linked to the administration of probiotics are as competitive exclusion of pathogenic bacteria ,,,,, as a source of nutrients enzymatic contribution to digestion ,,, as direct uptake of dissolved organic material mediated by the bacteria. Probiotics also act as enhancement of the immune response against pathogenic microorganisms [Figure 6].,,,,
| Conclusion|| |
The probiotics are most commonly used in many ways such as foods and drugs scientific research etc. and the probiotics' main important role is the development of the human animal health. Now, a day's probiotics are classified to uses of human health; the world health organization approved to uses of probiotics in human animals these are generally recognized as safe. In this review, probiotic and its secondary metabolites are used to the development of aquaculture therapeutic applications.
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Conflicts of interest
There are no conflicts of interest.
| References|| |
Gismondo MR, Drago L, Lombardi A. Review of probiotics available to modify gastrointestinal flora. Int J Antimicrob Agents 1999;12:287-92.
Fuller R. Probiotics in man and animals. J Appl Bacteriol 1989;66:365-78.
Mombelli B, Gismondo MR. The use of probiotics in medical practice. Int J Antimicrob Agents 2000;16:531-6.
Ouwehand AC, Kirjavainen PV, Shortt C, Salminen S. Probiotics: Mechanisms and established effects. Int Dairy J 1999;9:43-52.
Sullivan A, Nord CE. The place of probiotics in human intestinal infections. Int J Antimicrob Agents 2002;20:313-9.
Cherif A, Ouzari H, Daffonchio D, Cherif H, Ben Slama K, Hassen A, et al.
Thuricin 7: A novel bacteriocin produced by bacillus thuringiensis BMG1.7, a new strain isolated from soil. Lett Appl Microbiol 2001;32:243-7.
Duc le H, Hong HA, Barbosa TM, Henriques AO, Cutting SM. Characterization of bacillus probiotics available for human use. Appl Environ Microbiol 2004;70:2161-71.
Barbosa TM, Serra CR, La Ragione RM, Woodward MJ, Henriques AO. Screening for bacillus isolates in the broiler gastrointestinal tract. Appl Environ Microbiol 2005;71:968-78.
Hong P, Liu XS, Zhou Q, Lu X, Liu JS, Wong WH, et al.
Aboosting approach for motif modeling using chIP-chip data. Bioinformatics 2005;21:2636-43.
Gatlin D 3rd
, Li P. Use of Diet Additives to Improve Nutritional Value of Alternative Protein Sources. New York: Haworth Press; 2008. p. 501-22.
Ziemer CJ, Gibson GR. An overview of probiotics, prebiotics and synbiotics in the functional food concept: Perspectives and future strategies. Int Dairy J 1998;8:473-9.
Kesarcodi-Watson A, Kaspar H, Lategan MJ, Gibson L. Probiotics in aquaculture: The need, principles and mechanisms of action and screening processes. Aquaculture 2008;274:1-14.
Gibson GR, Roberfroid MB. Dietary modulation of the human colonic microbiota: Introducing the concept of prebiotics. J Nutr 1995;125:1401-12.
Ringø E, Gatesoupe FJ. Lactic acid bacteria in fish: A review. Aquaculture 1998;160:177-203.
Vijayaram S, Kannan S. Studies on probiotic analysis in the gut region of fresh water fishes in periyar lake, Kerala. Int J Pharm Sci Res Rev 2014;3:17-20.
Nikoskelainen S, Ouwehand AC, Bylund G, Salminen S, Lilius EM. Immune enhancement in rainbow trout (Oncorhynchus mykiss
) by potential probiotic bacteria (Lactobacillus rhamnosus
). Fish Shellfish Immunol 2003;15:443-52.
Panigrahi A, Azad I. Microbial intervention for better fish health in aquaculture: The Indian scenario. Fish Physiology and Biochemistry 2007;33:429-40.
Alderman D, Hastings T. Antibiotic use in aquaculture: Development of antibiotic resistance–potential for consumer health risks. International Journal of Food Science & Technology 1998;33:139-55.
Villamil L, Tafalla C, Figueras A, Novoa B. Evaluation of immunomodulatory effects of lactic acid bacteria in turbot (Scophthalmus maximus
). Clin Diagn Lab Immunol 2002;9:1318-23.
Smith P, Davey S. Evidence for the competitive exclusion of Aeromonas salmonicida
from fish with stress-inducible furunculosis by a fluorescent pseudomonad. J Fish Dis 1993;16:521-4.
Elrod-Erickson M, Mishra S, Schneider D. Interactions between the cellular and humoral immune responses in drosophila. Curr Biol 2000;10:781-4.
Balcázar JL, de Blas I, Ruiz-Zarzuela I, Cunningham D, Vendrell D, Múzquiz JL, et al.
The role of probiotics in aquaculture. Vet Microbiol 2006;114:173-86.
Rinkinen M, Jalava K, Westermarck E, Salminen S, Ouwehand AC. Interaction between probiotic lactic acid bacteria and canine enteric pathogens: A risk factor for intestinal Enterococcus faecium
colonization? Vet Microbiol 2003;92:111-9.
Verschuere L, Rombaut G, Sorgeloos P, Verstraete W. Probiotic bacteria as biological control agents in aquaculture. Microbiol Mol Biol Rev 2000;64:655-71.
Das S, Ward LR, Burke C. Prospects of using marine actinobacteria as probiotics in aquaculture. Appl Microbiol Biotechnol 2008;81:419-29.
Demain AL, Sanchez S. Microbial drug discovery: 80 years of progress. J Antibiot (Tokyo) 2009;62:5-16.
Gill HS, Guarner F. Probiotics and human health: A clinical perspective. Postgrad Med J 2004;80:516-26.
Ringo E. Lactic acid bacteria in fish and fish farming. Food Science and Technology. Vol. 139. New York: Marcel Dekker; 2004. p. 581-610.
Rengpipat S, Phianphak W, Piyatiratitivorakul S, Menasveta P. Effects of a probiotic bacterium on black tiger shrimp Penaeus monodon
survival and growth. Aquaculture 1998;167:301-13.
Pandiyan P, Balaraman D, Thirunavukkarasu R, George EG, Subaramaniyan K, Manikkam S, et al
. Probiotics in aquaculture. Drug Invent Today 2013;5:55-9.
Mahajan GB, Shanbhag P, Sivaramakrishnan H. Mode of Action of Antibiotic PM181104 on Bacteria, Abstract Registration No. 5SN3KNFPHL 1st
Global Forum on Bacterial Infections: Balancing Treatment Access Antibiotic Resistance 2011. The Center for Disease Dynamics Economics Policy, New Delhi, India; 2011.
Sihag RC, Sharma P. Probiotics: The new ecofriendly alternative measures of disease control for sustainable aquaculture. J Fisheries Aquatic Sci 2012;7:72.
Vijayaram S, Kannan S. Antagonistic activity of bacillus cereus against human and fish pathogenic bacteria. Int J Pharm Bio Sci 2015;6:60-8.
Nogami K, Maeda M. Bacteria as biocontrol agents for rearing larvae of the crab Portunus trituberculatus
. Can J Fisheries Aquatic Sci 1992;49:2373-6.
Nogami K, Hamasaki K, Maeda M, Hirayama K. Biocontrol method in aquaculture for rearing the swimming crab larvae Portunus trituberculatus
. Hydrobiologia 1997;358:291-5.
Hansen GH, Olafsen JA. Bacterial colonization of cod (Gadus morhua
L.) and halibut (Hippoglossus hippoglossus
) eggs in marine aquaculture. Appl Environ Microbiol 1989;55:1435-46.
Olsson JC, Westerdahl A, Conway PL, Kjelleberg S. Intestinal colonization potential of turbot (Scophthalmus maximus
)- and dab (Limanda limanda
)-associated bacteria with inhibitory effects against Vibrio anguillarum
. Appl Environ Microbiol 1992;58:551-6.
Vijayaram S, Kannan S, Muthukumar S. Isolation characterization of probiotic bacteria isolated from diverse fish fauna of the trodden Vaigai river at Theni district. J Chem Pharm Res 2016;8:883-9.
Gatlin DM. Nutrition Fish Health. San Diego, California, USA: Academic Press; 2002.
Irianto A, Austin B. Use of probiotics to control furunculosis in rainbow trout, Oncorhynchus mykiss
(Walbaum). J Fish Dis 2002;25:333-42.
Patterson JA, Orban JI, Sutton AL, Richards GN. Selective enrichment of bifidobacteria in the intestinal tract of broilers by thermally produced kestoses and effect on broiler performance. Poult Sci 1997;76:497-500.
Spanggaard B, Huber I, Nielsen J, Nielsen T, Gram L. Proliferation and location of Vibrio anguillarum
during infection of rainbow trout, Oncorhynchus mykiss
(Walbaum). J Fish Dis 2000;23:423-7.
Sakata H, Taira M, Mine S, Murata A. Linkage of perception action in the parietal association cortex of the monkey. Int Union Physiol Sci 1989;17:1056.
Dixon-Krauss L. Vygotsky in the Classroom: Mediated Literacy Instruction and Assessment. White Plains: ERIC; 1996.
Fuente Mde L, Miranda CD, Jopia P, González-Rocha G, Guiliani N, Sossa K, et al.
Growth inhibition of bacterial fish pathogens and quorum-sensing blocking by bacteria recovered from chilean salmonid farms. J Aquat Anim Health 2015;27:112-22.
Atlas RM, BR. Microbial Ecology: Fundamentals Applications. New York: Benjamin Cummings Pub. Co.; 1993.
Vijayaram Seerangaraj KS, Vijayakumar U, Meganathan B, Seerangaraj V, Selvam S, Rajendran V, et al
. Isolation characterization of bioactive compounds for Bacillus cereus
and Bacillus subtilis
from Oreochromis mossambicus
and Labeo rohita
. Int J Pharm Sci Rev Res 2017;43:71-7.
Newman DJ, Cragg GM. Natural products as sources of new drugs over the last 25 years. J Nat Prod 2007;70:461-77.
Butler MS. Natural products to drugs: Natural product derived compounds in clinical trials. Nat Prod Rep 2005;22:162-95.
Guarner F, Schaafsma GJ. Probiotics. Int J Food Microbiol 1998;39:237-8.
Nikoskelainen S, Ouwehand A, Salminen S, Bylund G. Protection of rainbow trout (Oncorhynchus mykiss
) from furunculosis by Lactobacillus rhamnosus
. Aquaculture 2001;198:229-36.
You HJ, Oh DK, Ji GE. Anticancerogenic effect of a novel chiroinositol-containing polysaccharide from Bifidobacterium bifidum
BGN4. FEMS Microbiol Lett 2004;240:131-6.
Abdelali H, Cassand P, Soussotte V, Daubeze M, Bouley C, Narbonne JF, et al.
Effect of dairy products on initiation of precursor lesions of colon cancer in rats. Nutr Cancer 1995;24:121-32.
Onoue M, Kado S, Sakaitani Y, Uchida K, Morotomi M. Specific species of intestinal bacteria influence the induction of aberrant crypt foci by 1,2-dimethylhydrazine in rats. Cancer Lett 1997;113:179-86.
Rowland IR, Rumney CJ, Coutts JT, Lievense LC. Effect of bifidobacterium longum and inulin on gut bacterial metabolism and carcinogen-induced aberrant crypt foci in rats. Carcinogenesis 1998;19:281-5.
Singh J, Rivenson A, Tomita M, Shimamura S, Ishibashi N, Reddy BS, et al.
Bifidobacterium longum, a lactic acid-producing intestinal bacterium inhibits colon cancer and modulates the intermediate biomarkers of colon carcinogenesis. Carcinogenesis 1997;18:833-41.
Sekine K, Ohta J, Onishi M, Tatsuki T, Shimokawa Y, Toida T, et al.
Analysis of antitumor properties of effector cells stimulated with a cell wall preparation (WPG) of bifidobacterium infantis. Biol Pharm Bull 1995;18:148-53.
Oda M, Hasegawa H, Komatsu S, Kambe M, Tsuchiya F. Anti-tumor polysaccharide from Lactobacillus
sp. Agric Biol Chem 1983;47:1623-5.
Vijayarama S, Robinsonb JP, Kannana S. Synthesis of antibacterial and anticancer substances by Bacillus
sp. PRV3 and Bacillus
sp. PRV23, an intestinal probiotics of Indian fresh water fish. Int J Pharm Sci Rev Res 2017;43:208-19.
Kamei Y, Yoshimizu M, Ezura Y, Kimura T. Screening of bacteria with antiviral activity from fresh water salmonid hatcheries. Microbiol Immunol 1988;32:67-73.
Direkbusarakom S, Yoshimizu M, Ezura Y, Ruangpan L, Danayadol Y. Vibrio spp. the dominant flora in shrimp hatchery against some fish pathogenic viruses. J Mar Biotechnol 1998;6:266-7.
Austin B, Baudet E, Stobie M. Inhibition of bacterial fish pathogens by Tetraselmis suecica
. J Fish Dis 1992;15:55-61.
Balcazar J, Vendrell D, Blas ID, Ruiz-Zarzuela I, Muzquiz J. Probiotics: A tool for the future of fish and shellfish health management. J Aquaculture Trop 2004;19:239-42.
Vine NG, Leukes WD, Kaiser H.In vitro
growth characteristics of five candidate aquaculture probiotics and two fish pathogens grown in fish intestinal mucus. FEMS Microbiol Lett 2004;231:145-52.
Garriques D, Arevalo G, editors. An Evaluation of the Production and Use of a Live Bacterial Isolate to Manipulate the Microbial Flora in the Commercial Production of Penaeus vannamei
postlarvae in Ecuador. Swimming through Troubled Water Proceedings of the Special Session on Shrimp Farming, Aquaculture; 1995.
Prieur G, Nicolas JL, Plusquellec A, Vigneulle M. Probiotic treatment. Aquaculture 1990;245:249-61.
Andlid T, Juárez RV, Gustafsson L. Yeast colonizing the intestine of rainbow trout (Salmo gairdneri
) and turbot (Scophtalmus maximus
). Microb Ecol 1995;30:321-34.
Scholz U, Diaz GG, Ricque D, Suarez LC, Albores FV, Latchford J. Enhancement of vibriosis resistance in juvenile Penaeus vannamei
by supplementation of diets with different yeast products. Aquaculture 1999;176:271-83.
Ben Amor K, Vaughan EE, de Vos WM. Advanced molecular tools for the identification of lactic acid bacteria. J Nutr 2007;137:741S-7S.
Timmerman HM, Koning CJ, Mulder L, Rombouts FM, Beynen AC. Monostrain, multistrain and multispecies probiotics – A comparison of functionality and efficacy. Int J Food Microbiol 2004;96:219-33.
Song MX, Deng XQ, Wei ZY, Zheng CJ, Wu Y, An CS, et al.
Synthesis and antibacterial evaluation of (S, Z)-4-methyl-2-(4-oxo-5-((5-substituted phenylfuran-2-yl) methylene)-2-thioxothiazolidin-3-yl) Pentanoic acids. Iran J Pharm Res 2015;14:89-96.
Linares DM, Gómez C, Renes E, Fresno JM, Tornadijo ME, Ross RP, et al.
Lactic acid bacteria and bifidobacteria with potential to design natural biofunctional health-promoting dairy foods. Front Microbiol 2017;8:846.
Zorriehzahra MJ, Delshad ST, Adel M, Tiwari R, Karthik K, Dhama K, et al.
Probiotics as beneficial microbes in aquaculture: An update on their multiple modes of action: A review. Vet Q 2016;36:228-41.
Bermudez-Brito M, Plaza-Díaz J, Muñoz-Quezada S, Gómez-Llorente C, Gil A. Probiotic mechanisms of action. Ann Nutr Metab 2012;61:160-74.
Khoder G, Al-Menhali AA, Al-Yassir F, Karam SM. Potential role of probiotics in the management of gastric ulcer. Exp Ther Med 2016;12:3-17.
Kumar K, Sastry N, Polaki H, Mishra V. Colon cancer prevention through probiotics: An overview. J Cancer Sci Ther 2015;7:81-92.
Hayatsu H, Hayatsu T. Suppressing effect of lactobacillus casei administration on the urinary mutagenicity arising from ingestion of fried ground beef in the human. Cancer Lett 1993;73:173-9.
Conway PL, Gorbach SL, Goldin BR. Survival of lactic acid bacteria in the human stomach and adhesion to intestinal cells. J Dairy Sci 1987;70:1-2.
Kumar V, Roy S, Meena DK, Sarkar UK. Application of probiotics in shrimp aquaculture: Importance, mechanisms of action, and methods of administration. Rev Fish Sci Aquaculture 2016;24:342-68.
Saarela M, Lähteenmäki L, Crittenden R, Salminen S, Mattila-Sandholm T. Gut bacteria and health foods – The European perspective. Int J Food Microbiol 2002;78:99-117.
Goldin BR. Intestinal microflora: Metabolism of drugs and carcinogens. Ann Med 1990;22:43-8.
[Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6]
[Table 1], [Table 2]
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