| ORIGINAL ARTICLE |
|
| Year : 2019 | Volume
: 3
| Issue : 1 | Page : 39-41 |
|
|
Effect of ATP-Binding cassette, Sub-Family B polymorphism on plasma nevirapine and efavirenz levels in human immunodeficiency virus with tuberculosis-infected cases: A molecular structure analysis
Pathum Sookaromdee1, Viroj Wiwanitkit2
1 TWS Medical Center, Bangkok, Thailand
2 Department of Biological Science, Josepeh Ayobabalola University, Ikeji-Arakeji, Osun State, Nigeria
Correspondence Address:
Dr. Pathum Sookaromdee
TWS Medical Center, Bangkok
Thailand
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/bbrj.bbrj_23_19
|
|
|
Background: Tuberculosis (TB) is an important infection that is usually seen in the patient with underlying human immunodeficiency virus (HIV) infection. An important concern on the cases with HIV/TB is the management of HIV by antiretroviral drug treatment (antiretroviral therapy). The effect of underlying genetic factor is interesting. The effect of adenosine triphosphate-binding cassette, sub-family B (ABCB-1) polymorphism on plasma nevirapine and efavirenz levels is inconclusive. Methods: The authors perform standard molecular structure analysis to assess the effect of C and T alleles of ABCB-1 C3435T polymorphism. The phenotype expressions, reflected by nevirapine and efavirenz levels, are comparatively studied. Results: With focus on 3435 position, the ratio of derived molecular weight after quantum assessment, comparing CC to CT and TT genotypes, is equal to 1:1.068:1.135. Conclusion: The authors can identify the effect of ABCB-1 on the plasma nevirapine and efavirenz levels in HIV/TB patients.
|
|
|
|
| [FULL TEXT] [PDF]* |
|
 |
|
