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Year : 2021  |  Volume : 5  |  Issue : 2  |  Page : 110-120

A review on Coronavirus Disease and potentially active drugs targeting Coronavirus

1 Department of Chemistry, I.K. Gujral Punjab Technical University, Jalandhar, India
2 Department of Chemistry, Laureate Institute of Pharmacy, Kangra, Himachal Pradesh, India
3 Department of Pharmaceutical Sciences, Ch. Bansi Lal University, Bhiwani, India
4 Department of Chemistry, S.P. Jain College, Veer Kunwar Singh University, Sasaram, Bihar, India
5 Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India
6 Department of Ayush, Drugs Testing Laboratory Avam Anusandhan Kendra, Raipur, Chhattisgarh, India

Correspondence Address:
Dr. Kamal Shah
Institute of Pharmaceutical Research, GLA University, Mathura - 281 406, Uttar Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/bbrj.bbrj_14_21

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a virus with single positive-strand RNA, having glycoproteins projection on envelopes so reveals a halo-like appearance or corona. Coronavirus is of four types: (1) α-coronavirus (α-COV); (2) β-coronavirus (β-COV); (3) δ-coronavirus (δ-COV); and (4) γ-coronavirus (γ-COV) and belongs to family Coronaviridae and subfamily Coronavirinae. Coronaviruses are the normal pathogens that cause broad band of gastrointestinal and respiratory diseases in domestic as well as wild animals such as pigs, birds, and rodents. Coronavirus is highly infectious in case of elders for mortality rate. The elder peoples are at 2-fold higher risk as compared to the younger population and the greater part of the population dying from coronavirus disease (COVID-19) is male. The virus enters into the body by the mouth, eyes, or nose, then particles march inside of the body by different pathways and affect vital organs in severe ways such as liver, heart muscle, blood vessels, kidneys, central nervous system, etc. Right now, the only solution to avoid COVID-19 infection is “precautions.” Different companies of different countries at different steps are in race to develop effective medicines for treatment and management of the same. Here, in this review, we tried to give an overview of all about SARS-CoV-2, COVID-19 infection, pathophysiology, mechanisms, and various treatment trials.

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