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ORIGINAL ARTICLE
Year : 2021  |  Volume : 5  |  Issue : 2  |  Page : 161-165

The effect of 16 Arg/Gly β2–adrenergic receptors gene polymorphism on pulmonary function in asthmatic children treated with nebulized salbutamol


1 Department of Pharmacology, College of Pharmacy, University of Karbala, Karbala, Iraq
2 College of Medicine, University of Karbala, Karbala, Iraq
3 Department of Pharmacology, Karbala Teaching Hospital for Children, Karbala, Iraq

Correspondence Address:
Ayat Sahib Mohammed
Department of Pharmacology, College of Pharmacy, University of Karbala, Karbala
Iraq
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/bbrj.bbrj_36_21

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Background: The β2-adrenergic receptor gene is a typical candidate for the study of genetic polymorphism, the biological relevance, and clinical consequences of polymorphisms. Many patients with asthma do not respond to β2-agonist; in addition, a wide interindividual variability in pharmacological response exists, likely because of the interaction between clinical, environmental, and genetic factors. Methods: A total of 80 asthmatic children, including 55 males and 25 females with acute attacks ages range between 5 and 18 years, attended the Respiratory Clinic at Karbala Pediatric Hospital, allele-specific polymerase chain reaction was performed to determine SNP of β2-adrenergic receptor gene at nucleic acid 46 (16 amino acid position). Results: Asthmatic children having GG genotype showed significant increase (P < 0.05) in all the recorded lung function parameter (forced expiratory volume in 1 s [FEV1], forced vital capacity [FVC], FEV1/FVC and FEV1% predicted) after treatment with nebulized salbutamol while those having AA and AG genotypes showed significant (increase) improvement (P < 0.05) only in FEV1, FVC, and FEV1% predicted after treatment with nebulized salbutamol and showed no significant increase (P > 0.05) in FEV1/FVC ratio after treatment with nebulized salbutamol, patients having GG genotype of 16Arg/Gly SNP showed highest change (increase) in FEV1 (204.44 ± 175.35) ml and in FEV1% predicted (15.22 ± 14.75) % after treatment with nebulized salbutamol in compared with other genotypes groups, although this change is not statistically significant (P > 0.05). Conclusion: Asthmatic children having GG (Gly16Gly) genotype showed better improvement in lung function after nebulized salbutamol in compared with those having AA (Arg16Arg) and those having heterozygous AG (Arg16Gly) during mild-to-moderate acute asthma attacks.


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