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ORIGINAL ARTICLE
Year : 2021  |  Volume : 5  |  Issue : 2  |  Page : 180-183

Detection of Epstein–Barr virus in prostate tissue from prostatic cancer patients in Iraq


Department of Medical Microbiology, Al-Sadr Medical City Hospital, Kufa, Iraq

Correspondence Address:
Anwar Abd Hashim Al-Ramahy
Department of Medical Microbiology, Al-Sadr Medical City Hospital, Kufa
Iraq
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/bbrj.bbrj_57_21

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Introduction: The prostatic tumor was the third form of cancer in males being more than 55 years of age, after the pulmonary and colon cancer. The prostate infected by many viruses causing repeated or chronic inflammation or enhance carcinogenesis. The aim of this study was to determine the presence and prevalence of Epstein–Barr virus (EBV) in the prostate tissue of patients with prostate cancer. Methods: Prostate tissue samples were collected from paraffin embedding block of 70 patients diagnosed with EBV from archives of AL-Sadder Hospital in AL-Najaf City and some archives of private histopathology laboratories from January 2016 to the December of the same year. We investigated the presence of EBV DNA by using the polymerase chain reaction (PCR). Results: The sample size was 60 patients and 10 as controls. The present study shows that 7/60 prostatic patients have EBV. Five patients of them have a malignancy prostatic tumor and only two with a benign prostatic tumor. On the other hand, there are 53/60 prostatic patients without EBV. Conclusions: EBV gene sequences were identified in benign and prostate cancer specimens. These sequences were located in the nuclei of prostate epithelial cells. The presence of EBV gene sequences in some of the benign and malignant prostate specimens is particularly noteworthy because of recent experimental evidence demonstrating that EBV can increase the proliferation of cultured cervical cells.


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