| REVIEW ARTICLE |
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| Year : 2021 | Volume
: 5
| Issue : 4 | Page : 374-379 |
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Co-regulatory network of transcription factor and microrna: A key player of gene regulation
Akshara Pande
School of Computing, Graphic Era Hill University, Dehradun, Uttarakhand, India
Correspondence Address:
Akshara Pande
School of Computing, Graphic Era Hill University, Dehradun, Uttarakhand
India
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/bbrj.bbrj_182_21
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Transcription factor (TF) and microRNA (miRNA) interaction plays a vital role in the regulation of biological networks. TFs and miRNAs control the gene expression: TF at transcriptional level by affecting the messenger RNA (mRNA) transcription and miRNA at posttranscriptional level by affecting the transcription and translation. Furthermore, sometimes, both miRNAs and TFs regulate one another's expressions; as a consequence, this may influence the expression of the target gene. In order to understand the main co-regulatory mechanisms underlying, it is important to identify biologically relevant network motifs involving TFs, miRNAs and their targets. The present study focuses on TF, miRNA and target gene interactions.
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