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  Indian J Med Microbiol
 

Figure 1: Transcriptional/translational regulation of Escherichia coli (enteropathogenic Escherichia coli) locus of enterocyte effacement and pEAF genes (adopted from Platenkamp and Mellies, 2018). The environmental signals are transmitted through the phosphorelay systems, sRNAs, stringent responses, quorum-sensing responses, and envelope stress responses which influence the transcription of the locus of enterocyte effacement and pEAF. The LEE1 operon (encoding Ler) is regulated by (1) the nucleoid-associated proteins: Ler, H-NS, Hha, Fis, and IHF; (2) the pEAF-encoded regulator PerC, (3) locus of enterocyte effacement-encoded GrlA/GrlR, (4) the quorum-sensing (QS) factors QseA, BipA, and GrvA. RelA, CpxR, and QseA regulate the per operon on the pEAF; and PerA promotes bfp transcription and auto-activates per gene

Figure 1: Transcriptional/translational regulation of <i>Escherichia coli</i> (enteropathogenic <i>Escherichia coli</i>) locus of enterocyte effacement and pEAF     genes (adopted from Platenkamp and Mellies, 2018). The environmental signals are transmitted through the phosphorelay systems, sRNAs, stringent responses, quorum-sensing responses, and envelope stress responses which influence the transcription of the locus of enterocyte effacement and pEAF. The <i>LEE1</i> operon (encoding Ler) is regulated by (1) the nucleoid-associated proteins: Ler, H-NS, Hha, Fis, and IHF; (2) the pEAF-encoded regulator PerC, (3) locus of enterocyte effacement-encoded GrlA/GrlR, (4) the quorum-sensing (QS) factors QseA, BipA, and GrvA. RelA, CpxR, and QseA regulate the <i>per</i> operon on the pEAF; and PerA promotes <i>bfp</i> transcription and auto-activates <i>per</i> gene